There are a number of reasons why alpha inhibition is specifically useful. First, while the beta-adrenergic system primarily controls lipolysis during periods of intense activity, during rest, which makes up most of our day, the alpha-adrenergic system is in control. Also, "stubborn fat" areas – usually the abdominal area in men and the glutofemoral area in women – contain a higher ratio of alpha receptors, making yohimbine particularly effective in these areas (whereas other drugs that increase NE may be somewhat counterproductive). Finally, alpha blockade increases blood flow in adipose tissue, which prevents fat from being retained in
the area.
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